李雨晴
苏州大学功能纳米与软物质研究院（funsom）副教授，硕士生导师。硕士毕业于中南大学化学化工学院，2021年博士毕业于加拿大滑铁卢大学化学系(university of waterloo)，2022年起在苏州大学funsom从事博士后研究，随后入职funsom任副教授。
所在课题组：
刘庄教授课题组
研究方向及成果：
近年来主要聚焦靶向蛋白降解领域，致力于针对传统药物难以靶向或疗效不佳的致病蛋白进行活性调控。基于化学生物学、分子工程等多学科方法，利用功能核酸、融合蛋白等分子工具，通过理性设计和定向进化等手段，实现高选择性、高安全性的致病蛋白降解。此外，还致力于开发基于功能核酸的诊疗新策略。目前以第一作者和共同通讯作者在j. am. chem. soc., chem, angew. chem. int. ed., acs central science, chemical science等国际权威学术期刊发表论文18篇。在学术期刊frontiers in chemistry担任review editor（in section of analytical chemistry）和guest associate editor（in section of medical and pharmaceutical chemistry）。
个人荣誉：
海外高层次青年人才b类
江苏省卓越博士后计划
r.h.f. manske prize (加拿大滑铁卢大学，1/27，唯一获奖人）
provost doctoral entrance award (pdea) for women
承担项目：
国家自然科学基金青年项目，在研，主持
江苏省自然科学基金青年项目，在研，主持
中国博士后科学基金特别资助站前项目，已结题，主持
代表性论文:
x. wang#,l. tian#, y. li*, w. yao, j. zhu, h. zhou, g. chen, t. chen, z. liu, w. tan*, y. yang* a universal albumin drugs-cored spherical nucleic acid (ad-sna) platform for targeted drug delivery, angew. chem. int. ed., 2025, in press.
j. chen, y. li*, x. liu, h. li, j. zhu, r. ma, l. tian, l. yu. j. li, z. liu, w. tan, y. yang* “antigen spatial matching polyaptamer nanostructure for blocking coronavirus infection and alleviating inflammation”, chem, 2024, doi:10.1016/j.chempr.2024.10.021.
y. li, x. liu, l. yu, x. huang, x. wang, d. han*, y. yang*, z. liu* “covalent lytac enabled by dna aptamers for immune checkpoint degradation therapy”,j. am. chem. soc., 2023, 145, 45, 24506–24521.
y. li, h. gao, z. qi, z. huang, l. ma, j. liu* “freezing‐assisted conjugation of unmodified diblock dna to hydrogel nanoparticles and monoliths for dna and hg2 sensing”, angew. chem. int. ed., 2021, 60 (23), 12985-12991.
y. li, b. liu, z. huang and j. liu* “engineering base-excised aptamers for highly specific recognition of adenosine”, chemical science, 2020, 11 (10), 2735-2743.
r. yuan#,y. li#, s. han#, x. chen, j. chen, j. he, h. gao*, y. yang* “fe-curcumin nanozyme-mediated reactive oxygen species scavenging and anti-inflammation for acute lung injury”,acs central science, 2022, 8 (1), 10–21.
y. li, j. liu* “nanozyme’s catching up: activity, specificity, reaction conditions and reaction types”, materials horizons, 2020, 8, 336-350.
z. cheng1, j. wei1, l. gu, l. zou, t. wang, l. chen, y. li*, y. yang, p. li* “dnazyme-based biosensors for mercury (ii) detection: rational construction, advances and perspectives”,journal of hazardous materials, 2022, 431, 128606.
y. li, j. chen, j. wei, x. liu, l. yu, l. yu*, d. ding*, y. yang* “metallic nanoplatforms for covid‑19 diagnostics: versatile applications in the pandemic and post‑pandemic era”, journal of nanobiotechnology, 2023, 21 (1), 255.
y. li, j. liu* “highly specific recognition of guanosine using engineered base excised aptamers”, chemistry–a european journal, 2020, 26 (60), 13644-13651.
y. li, m. zandieh, and j. liu* “modulation of dnazyme activity via butanol dehydration”, chemistry–an asian journal, 2021, 16 (24): 4062-4066.
尊龙凯时的联系方式：
江苏省苏州市工业园区仁爱路199号
邮箱：yqli719@suda.edu.cn
责任编辑：杨娟