程亮教授课题组在sci. adv.上发表论文-尊龙凯时

题目：

bimetallic peroxide nanoparticles induce panoptosis by disrupting ion homeostasis for enhanced immunotherapy

作者：

guanghui hou¹, youdong chen¹, huali lei¹, yujie lu^1,2, lin liu¹, zhihui han¹, shumin sun¹, jingrui li¹, liang cheng¹*

单位：

¹institute of functional nano & soft materials (funsom), jiangsu key laboratory for carbon-based functional materials & devices, soochow university, suzhou 215123, china.

²institute of state key laboratory of targeting oncology, national center for international research of bio-targeting theranostics, guangxi key laboratory of bio-targeting theranostics, collaborative innovation center for targeting tumor diagnosis and therapy, guangxi medical university, nanning, guangxi 530021, china.

摘要：

panoptosis has recently emerged as a potential approach to improve the immune microenvironment. however, current methods for inducing panoptosis are limited. herein, through biological screening, the rational use of the nutrient metal ions cu²  and zn²  had great potential to induce panoptosis. inspired by these findings, we successfully developed hydrazided hyaluronic acid-modified zinc copper oxide（hzco） nanoparticles as a panoptosis inducer to potentiate immunotherapy. bioactive hzco actively delivered cu²  and zn²  while disrupting the cellular intrinsic ion metabolism pathway, resulting in double-stranded dna release and organelle damage in cancer cells. simultaneously, this process triggered the formation of panoptosome and the activation of panoptosis. hzco-induced panoptosis inhibited tumor growth and activated potent antitumor immune response, thereby enhancing the effectiveness of anti–programmed cell death 1 therapy. overall, our work provides an insight into the development of panoptosis inducers and the design of synergistic immunotherapy strategies.

影响因子：

11.7

分区情况：

一区

链接：

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