汪超教授课题组在proc. natl. acad. sci.上发表论文-尊龙凯时

题目：

engineering bacteria for cancer immunotherapy by inhibiting ido activity and reprogramming cd8 t cell response

作者：

heng wang¹, fang xu¹*, chenlu yao¹, huaxing dai¹, jialu xu¹, bingbing wu¹, bo tian², xiaolin shi³, chao wang¹*

单位：

¹laboratory for biomaterial and immunoengineering, institute of functional nano and soft materials (funsom), soochow university, suzhou, jiangsu 215123, china.

²department of orthopedics, the second affiliated hospital of soochow university, suzhou, jiangsu 215004, china.

³medical college of soochow university, suzhou 215123, china.

摘要：

inhibiting indoleamine 2,3 dioxygenase (ido) for anticancer therapy has garnered significant attention in recent years. however, current ido inhibitors face significant challenges which limit their clinical application. here, we genetically engineered a high tryptophan-expressing clostridium butyricum (l-trp cb) strain that can colonize tumors strictly following systemic administration. we revealed that butyrate produced by l-trp cb can inhibit ido activity, preventing tryptophan catabolism and kynurenine accumulation in tumors. in addition, the large released tryptophan by l-trp cb can provide discrete signals that support cd8 t cell activation and energy metabolism within the tumor microenvironment. we observed that l-trp cb significantly restored the proportion and function of cd8 t cells, leading to significantly delayed tumor growth in both mouse and rabbit multiple tumor models with limited side effects. we here provide a synthetic biology treatment strategy for enhanced tumor immunotherapy by inhibiting ido activity and reprogramming cd8 t cell response in tumors.

影响因子：

9.4

分区情况：

一区

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