题目： | manganese galvanic cells intervene in tumor metabolism to reinforce cgas-sting activation for bidirectional synergistic hydrogen-immunotherapy |
作者： | nailin yang1,2#, shumin sun1#, jiachen xu3,4#, fei gong1#, huali lei1, yu hao1, zifan pei1, chenya wang1, qiao yu1, jihu nie1, nan jiang4, caifang ni4, and liang cheng1,2* |
单位： | 1institute of functional nano & soft materials (funsom), jiangsu key laboratory for carbon-based functional materials & devices, soochow university, suzhou 215123, china. 2macao institute of materials science and engineering, macau university of science and technology, macau sar 999078, china. 3department of vascular surgery and interventional radiology, the forth affiliated hospital of soochow university, medical center of soochow university, suzhou 215125, china. 4department of interventional radiology, the first affiliated hospital of soochow university, suzhou 215006, china. |
摘要： | the cgas-sting pathway is pivotal in initiating antitumor immunity. however, tumor metabolism, particularly glycolysis, negatively regulates the activation of the cgas-sting pathway. herein, mn galvanic cells (mng) are prepared via liquid-phase exfoliation and in situ galvanic replacement to modulate tumor metabolism, thereby enhancing cgas-sting activation for bidirectional synergistic h2-immunotherapy. the obtained mng can be etched by water, enabling efficient and sustained generation of h2 gas and mn2 . mng not only activated and amplified the cgas-sting pathway through the sustained release of mn2 but also regulated tumor glucose metabolism to inhibit the expression of three prime repair exonuclease 2 (trex2), thereby synergistically enhancing the activation of the cgas-sting pathway. the injection of mng into tumors resulted in a robust immune response, thereby providing favorable support for antitumor therapy. consequently, the combination of mng with immune checkpoint blockade therapy resulted in significant suppression of both primary tumors and distant tumors. furthermore, the mng-lipiodol dispersion exhibited remarkable efficacy in combination with transarterial embolization (tae)-gas-immunotherapy in a rabbit orthotopic liver tumor model. the present study underscores the significance of employing a metal galvanic cell strategy for enhanced immunotherapy, thereby offering a novel approach for rational design of bioactive materials to augment immunotherapeutic effectiveness. |
影响因子： | 27.4 |
分区情况： | 一区 |
链接： |
责任编辑：杜欣 |
