巢宇
副教授，硕士生导师
2015年获苏州大学生物功能材料专业学士学位；2020年获苏州大学化学专业博士学位；2020年至2023年在苏州大学从事博士后研究工作。2023年加入苏州大学功能纳米与软物质研究院，被聘为副教授。
主要成果和技术贡献：
近年来在纳米生物材料和肿瘤免疫疗法领域从事研究，开发了一系列以天然高分子材料为基础的药物递送体系，较为系统地探索了基于生物材料的局部肿瘤治疗及其介导的肿瘤免疫治疗新策略。此外，在天然高分子水凝胶载体的构建、小分子或大分子药物的装载和释放、肿瘤微环境调控以及生物材料增效免疫检查点阻断疗法等相关方面的研究中开展了一系列较为系统的工作，取得了具有一定国际影响力的研究成果。相关技术的临床转化工作正在稳步推进中，并已完成首例临床人体给药
在国际学术期刊共发表 sci 论文70 篇，其中，以第一作者（或共同一作）在 nature reviews bioengineering、nature biomedical engineering、science advances、advanced functional materials、nano letters、acs nano、biomaterials、small 等国际知名学术期刊上发表论文 10 篇。多篇文章被高频引用并得到了国家自然基金委和相关学术媒体的广泛报道。论文总引用超过7000 次，h 因子 44。申请发明专利 5 项，全部实现转让。
获奖情况：
2020年获苏州大学五四青年称号；
2020年获中国博士后创新人才支持计划
招生方向:
本研究方向热忱欢迎有志从事科研工作的本科生、研究生到课题组学习工作。招生方向为‘材料科学与工程’（04方向，生物纳米材料与生物医学材料）。欢迎具有化学、材料、或生物医学背景的同学报考。有疑问请随时邮件联系
发表论文：
http://www.researcherid.com/rid/k-9840-2015
https://scholar.google.com/citations?user=qxns1xuaaaaj&hl=zh-cn
代表性论文：
[1] yu chao, zhuang liu*,“biomaterials tools to modulate the tumour microenvironment in immunotherapy”, nature reviews bioengineering, 1, 125-138 (2023).
[2] zhu, wenjun┼; chao, yu┼; jin, qiutong; chen, linfu; shen, jing-jing; zhu, jiafei; chai, yu; lu, panhao; yang, nailin ; chen, muchao; yang, yang; chen, qian; liu, zhuang*, “oral delivery of therapeutic antibodies with a transmucosal polymeric carrier”, acs nano, 10.1021/acsnano.2c09266 (2023). (┼ equal contribution authors)
[3] yu chao, ting wei, qiaofeng li, bo liu, yu hao, muchao chen, yuzhe wu, fanxin song, qian chen*, zhuang liu*, metformin-containing hydrogel scaffold to augment car-t therapy against post-surgical solid tumors, biomaterials, 10.1016/j.biomaterials.2023.122052 (2023).
[4] qiaofeng li, yu chao*, bo liu, zhisheng xiao, zhijuan yang, yuzhe wu, zhuang liu*, “disulfiram loaded calcium phosphate nanoparticles for enhanced cancer immunotherapy”, biomaterials, 291,121880 (2022).
[5] yu chao, chao liang, huiquan tao, yaran du, di wu, ziliang dong, qiutong jin, guobin chen, jun xu, zhisheng xiao, qian chen, chao wang, jian chen, zhuang liu*. “localized cock-tail chemo-immunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.” science advances, 6(10), eaaz4204 (2020)
[6] yu chao, guobin chen, chao liang, jun xu, ziliang dong, xiao han, chao wang, zhuang liu*. “iron nanoparticles for low-power local magnetic hyperthermia in combination with immune checkpoint blockade for systemic” nano lett., 19(7), 4287- 4296 (2019)
[7] yu chao, qian chen*, zhuang liu*. “smart injectable hydrogels for cancer immunotherapy” adv. funct. mater.,1902785 (2019)
[8] yu chao, ligeng xu, chao liang, liangzhu feng, jun xu, ziliang dong, longlong tian, xuan yi, kai yang*, zhuang liu*. combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses nature biomedical engineering, 2, 611-621(2018)
[9] yu chao, chao liang, yu yang, guanglin wang, debabrata maiti, longlong tian, fei wang, wei pan, song wu*, kai yang*, zhuang liu*. highly effective radioisotope cancer therapy with a non-therapeutic isotope delivered and sensitized by nanoscale coordination polymers acs nano, 12 (8), 7519-7528 (2018)
[10] yu chao, guanglin wang, chao liang, xuan yi, xiaoyan zhong, jingjing liu, min gao, kai yang*, liang cheng*, zhuang liu*. “rhenium-188 labeled tungsten disulfide nanoflakes for self-sensitized, near-infrared enhanced radioisotope therapy” small, 12, 3967-3975 (2016)
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