题目： | zinc−nickel bimetallic hydroxide nanosheets activate the paraptosis−pyroptosis positive feedback cycle for enhanced tumor immunotherapy |
作者： | youdong chen1, yujie lu1, huali lei1, lin liu1, xianmin li1, yuqi yang1, shumin sun1, qiao yu1, li wang1, jie wu1,2, jingrui li1, guanghui hou1* and liang cheng1,2* |
单位： | 1institute of functional nano & soft materials (funsom), jiangsu key laboratory for carbon-based functional materials & devices, soochow university, suzhou 215123, china. 2macao institute of materials science and engineering, macau university of science and technology, taipa, macau sar 999078, china. |
摘要： | immunotherapy holds significant promise for cancer treatment. however, the highly immunosuppressive nature of solid tumors limits its effectiveness. herein, we developed bioactive zinc−nickel hydroxide (znni(oh)4) nano-sheets (nss) that can effectively initiate the paraptosis−pyroptosis positive feedback cycle through synergistic ionic effect, thereby mitigating the immunosuppression of solid tumors and enhancing the efficacy of immunotherapy. the acid-sensitive znni(oh)4 nss releases ni2 and zn2 in the weakly acidic tumor microenvironment. the released ni2 alleviated pyroptosis inhibition by inducing paraptosis and inhibiting autophagic flux. concurrently, ni2 triggered release of endogenous zn2 within the cell through a coordination competition mechanism, further amplifying zinc overload-mediated pyroptosis. interestingly, pyroptosis-associated oxidative stress and endoplasmic reticulum stress further promote ni2 -mediated paraptosis, forming a positive feedback loop between pyroptosis and paraptosis. this process not only effectively kills tumor cells but also stimulates a strong inflammatory response, enhancing the antitumor immune response and immunotherapy efficacy. overall, this study proposes an effective paraptosis−pyroptosis induction strategy based on metal ions and demonstrates the effectiveness of the positive feedback loop of paraptosis−pyroptosis in potentiating immunotherapy. |
影响因子： | 15.8 |
分区情况： | 一区 |
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